West Point Best Point IMO. Tons of great resources and loot. Close to Valley Station and Louisville. The American Tire is very useful for fixing up a trailer and a sweet ride. I like basing up in the three mansions or the hardware store apartment thing near the servo in the center of town.
I like Rosewood. Its small, with a low number of zombies and has a fire station and a police station. Its really easy to get set up here, but it kind of also encourages you to move to a different city because its so small so resources get used up pretty quickly.