I am fascinated by games with 2D art that still manage to give you a good scare. I guess what I find interesting is if a game can manage to translate the scares and audio design which we know from 3D environments and movies. I have never really played any though. I would love to hear some suggestions, especially with Halloween coming soon!
Signalis is my vote.
Even though it’s technically 2.5D I’d also recommend Inside.